| ABC of NC Fndn. | 1801 | Independent Charity | Dedicated to providing high-quality, evidence-based diagnostic, therapeutic, and educational services to people with autism spectrum disorder. |
| Aces for Autism | 3914 | Independent Charity | HOPE, JOY, SUCCESS Aces for Autism walks alongside individuals and families impacted by autism providing a variety of services to meet the needs of each individual. |
| ALS United NC | 1031 | Independent Charity | We provide care services, access to research and advocate for policies that directly impact the ALS Community in NC. |
| American Council of the Blind | 2486 | CHC: Creating Healthier Communities | Our mission is to increase the independence, security, equality of opportunity, and quality of life for all blind and visually impaired people. |
| Arc of NC | 1008 | CHC: Creating Healthier Communities | Committed to securing for all people with intellectual & developmental disabilities the opportunity to choose & realize their goals. |
| Arts Access | 7003 | Independent Charity | We create a positive impact at the intersection of arts, education, and disability. |
| Artspace | 6791 | Independent Charity | Artspace is a downtown Raleigh visual arts center connecting the public to North Carolina artists with no- or low-cost admission, cultural experiences, and arts education. |
| Assure the Future | 4099 | Independent Charity | Our mission is to provide enrichment activities not provided by the state for our residents, young children and adults with disabilities, of the J. Iverson Riddle Developmental Center. |
| Autism Society of NC | 2543 | Independent Charity | The Autism Society of North Carolina improves the lives of individuals with autism, supports their families, and educates communities. |
| Black Mountain Center Fndn. | 1537 | Independent Charity | We care for persons with intellectual disabilities and individuals with dementia, through programs, initiatives, activities and equipment. |
| Broad Street Clinic Fndn. | 3862 | Independent Charity | The Clinic provides dental and medical services to low income residents of Carteret County suffering from the 5 chronic diseases who can't afford physician visits. |
| Canine Companions for Independence | 1929 | America's Best Charities | A cold nose and a warm heart! Our companion dogs provide independence, assistance and friendship that transforms the lives of children and adults with disabilities. |
| Canines for Service | 3602 | Independent Charity | We partner Veterans with service-connected PTSD, TBI, MST, and/or mobility limitations with life-changing service dogs at no cost and without any fundraising obligation. |
| Caswell Center Fndn. | 2579 | Independent Charity | Enhance the quality of life for individuals with intellectual and developmental disabilities and their families in eastern North Carolina. |
| Center for Volunteer Caregiving | 3520 | Independent Charity | We support older adults and adults with disabilities who live independently with free volunteer services such as friendly visits, escorted transportation, and family caregiver respite visits. |
| Charles House Assoc. | 1552 | Independent Charity | Charles House provides support to elders and their caregiving families via a daytime eldercare program and a neighborhood eldercare home. |
| Chatham Trades | 3925 | Independent Charity | Provides employment & training for adults with intellectual & developmental disabilities including activities and skills for daily living, socialization, comm. awareness & integrated employment with supports. |
| Children’s Cancer Partners of the Carolinas | 4042 | Independent Charity | Carolinas-wide childhood cancer safety net ensuring equal access to care regardless how far, how often, how long with transportation, lodging, meals |
| Disability Rights & Resources | 3943 | Independent Charity | Creating a fully inclusive community in which all people, with and without disabilities, may pursue their own goals and choices for living and working together. |
| Disability Rights NC | 1544 | Independent Charity | The only organization dedicated to advancing and defending the rights of people with all types of disabilities, of all ages, across North Carolina |
| Disabled Children’s Fund | 2017 | America's Best Charities | Providing poor, disabled children worldwide with corrective surgery, free distribution of specialty wheelchairs, walkers, crutches, rehabilitation equipment and therapy. |
| Dogs for Deaf and Disabled Americans | 1913 | America's Best Charities | Independence and companionship for wounded warriors, autistic children, the deaf and disabled by providing custom-trained Service Dogs. Help provide these much needed Service Dogs! |
| Dogs for the Deaf | 5049 | America's Best Charities | Since 1977, Dogs for the Deaf has been rescuing, training and placing dogs from animal shelters to help people with different disabilities, challenges and needs. |
| Extraordinary Ventures | 4192 | Independent Charity | Extraordinary Ventures is a non-profit that operates small businesses to create meaningful employment opportunities for adults with Intellectual and Developmental Disabilities such as autism. |
| First In Families of NC | 3734 | Independent Charity | FIFNC partners with people experiencing disabilities and their families to meet self-defined goals by funding wellness requests crucial to access and contribute in their communities. |